Oscai L B, Essig D A, Palmer W K
Department of Physical Education, University of Illinois, Chicago 60680.
J Appl Physiol (1985). 1990 Nov;69(5):1571-7. doi: 10.1152/jappl.1990.69.5.1571.
The cellular control of intramuscular triglyceride (TG) metabolism involves two major identified lipases: hormone-sensitive lipase (HSL) and lipoprotein lipase (LPL). Recently, the presence of HSL in muscle has been unequivocally demonstrated. However, although it is thought that HSL is responsible for intramuscular TG lipolysis, direct evidence for this is lacking. There is evidence to suggest that HSL and LPL are simultaneously activated under a variety of conditions. The two muscle lipases appear to be turned on by the same signal and function as a coordinated unit in meeting the energy demands of muscle. At a time when HSL is presumably hydrolyzing endogenous TG, LPL is sent to the capillary beds in search of substrate. TG uptake from circulation is highly related to muscle LPL activity. Exercise training increases LPL activity in plasma and in parenchymal cells in muscle. These results suggest that training may increase the capacity to clear TG from circulation and that LPL might have a role in replenishing muscle TG stores that have been decreased with exercise.
肌肉内甘油三酯（TG）代谢的细胞控制涉及两种已明确的主要脂肪酶：激素敏感性脂肪酶（HSL）和脂蛋白脂肪酶（LPL）。最近，已明确证实肌肉中存在HSL。然而，尽管人们认为HSL负责肌肉内TG的脂解作用，但缺乏直接证据。有证据表明，在多种条件下HSL和LPL会同时被激活。这两种肌肉脂肪酶似乎由相同信号开启，并作为一个协同单位发挥作用，以满足肌肉的能量需求。在HSL可能正在水解内源性TG的时候，LPL会被输送到毛细血管床寻找底物。从循环中摄取TG与肌肉LPL活性高度相关。运动训练会增加血浆和肌肉实质细胞中的LPL活性。这些结果表明，训练可能会提高从循环中清除TG的能力，并且LPL可能在补充因运动而减少的肌肉TG储备方面发挥作用。
