Williams N E, Calvey T N, Chan K
Br J Anaesth. 1978 Oct;50(10):1065-7. doi: 10.1093/bja/50.10.1065.
The plasma concentration of neostigmine was measured in five patients during the antagonism of neuromuscular block. The concentration of the drug decreased rapidly between 2 and 5 min after administration, and then more slowly. Detectable concentrations of neostigmine were present in plasma after 60 min. In the five patients the distribution half-life of neostigmine was less than 1 min; the elimination half-life ranged from 15.4 to 30.1 min.
在五名患者进行神经肌肉阻滞拮抗过程中测定了新斯的明的血浆浓度。给药后2至5分钟内，药物浓度迅速下降，然后下降速度减慢。60分钟后血浆中仍存在可检测到的新斯的明浓度。在这五名患者中，新斯的明的分布半衰期小于1分钟；消除半衰期为15.4至30.1分钟。
