Cote P J, Wangsness P J, Varela-Alvarez H, Griel L C, Kavanaugh J F
J Anim Sci. 1982 Jan;54(1):89-94. doi: 10.2527/jas1982.54189x.
Glucose turnover and associated measurements were compared in genetically obese, slow-growing feral pigs (Ossabaw) and domestic lean, fast-growing (Yorkshire) pigs. Five Ossabaw and five Yorkshire pigs 8 wk of age were prepared with indwelling arterial catheters to facilitate injection of tracer and serial sampling of blood. After a 14-h fast, pigs were administered 100 muCi of glucose-6-3H in a single injection; 12 blood samples were obtained over the subsequent 4-h period to obtain tracer dilution curves. Plasma glucose concentrations were the same in both strains (88 mg/100 ml) prior to tracer injection and remained constant for the duration of the 4-h sampling period. Ossabaw pigs exhibited a smaller minimal glucose mass (144 vs 179 mg/kg body weight, P less than .01) and space (16 vs 20%, P less than .01) when compared with Yorkshire pigs. Glucose replacement rate was greater for Ossabaw pigs than for Yorkshire pigs (3.96 vs 2.97 mg.min-1.kg-1 body weight, P less than .001). Minimal transit time was less in Ossabaw pigs than Yorkshire pigs (36 vs 60 min, P less than .001), which reflected the greater rate of irreversible disposal of tracer from the glucose pool of Ossabaw pigs. In conclusion, under these experimental conditions and at similar fasting glucose concentrations, glucose turnover and metabolic clearance rates were greater in Ossabaw than Yorkshire pigs. The results suggest a greater rate of fasting liver gluconeogenesis during short-term fasting in the young Ossabaw than the Yorkshire pig.
对遗传性肥胖、生长缓慢的野猪（奥萨巴猪）和家养瘦肉型、生长迅速的猪（约克夏猪）的葡萄糖周转率及相关测量指标进行了比较。给5头8周龄的奥萨巴猪和5头8周龄的约克夏猪植入动脉留置导管，以便于注射示踪剂和连续采集血液样本。禁食14小时后，给猪单次注射100微居里的葡萄糖-6-³H；在随后的4小时内采集12份血样，以获得示踪剂稀释曲线。在注射示踪剂之前，两个品系猪的血浆葡萄糖浓度相同（88毫克/100毫升），并且在4小时采样期内保持恒定。与约克夏猪相比，奥萨巴猪的最小葡萄糖量（144对179毫克/千克体重，P<0.01）和空间（16%对20%，P<0.01）较小。奥萨巴猪的葡萄糖补充率高于约克夏猪（3.96对2.97毫克·分钟⁻¹·千克⁻¹体重，P<0.001）。奥萨巴猪的最小转运时间比约克夏猪短（36对60分钟，P<0.001），这反映了奥萨巴猪葡萄糖池示踪剂不可逆处置速率更高。总之，在这些实验条件下且空腹血糖浓度相似时，奥萨巴猪的葡萄糖周转率和代谢清除率高于约克夏猪。结果表明，幼年奥萨巴猪在短期禁食期间肝脏糖异生率高于约克夏猪。
