氟烷对大鼠损伤后葡萄糖代谢的影响。

Effects of halothane on glucose metabolism after injury in the rat.

作者信息

Heath D F, Frayn K N, Rose J G

出版信息

Br J Anaesth. 1978 Sep;50(9):899-904. doi: 10.1093/bja/50.9.899.

DOI:10.1093/bja/50.9.899

Abstract

The effects of halothane anaesthesia on glucose metabolism have been investigated in rats after a non-lethal scald injury. Anaesthesia was induced about 70 min after injury. Glucose metabolism was studied at two stages: during and shortly after induction, and about 2 h after induction. Comparisons were made with conscious rats at the corresponding times after injury. All rats were in an ambient temperature of 30 degrees C. During and shortly after the induction of anaesthesia, halothane caused a rapid increase in plasma glucose concentration, which by 30 min had begun to return to the values in injured controls; thus glucose production and utilization were increased. Insulin concentrations were increased also. However, after 2 h exposure halothane had decreased glucose production and utilization, as determined with [5-3H]- and [U-14C]-glucose, increased plasma concentrations of insulin and decreased liver concentrations of glycogen, that is it had exacerbated well-known effects of injury in the rat, including insulin resistance. Hyperglycaemia was not increased.

摘要

在大鼠遭受非致命性烫伤后，研究了氟烷麻醉对其葡萄糖代谢的影响。在受伤后约70分钟诱导麻醉。在两个阶段研究葡萄糖代谢：诱导期间及诱导后不久，以及诱导后约2小时。与受伤后相应时间的清醒大鼠进行比较。所有大鼠均处于30摄氏度的环境温度中。在麻醉诱导期间及诱导后不久，氟烷导致血浆葡萄糖浓度迅速升高，到30分钟时已开始恢复到受伤对照组的水平；因此葡萄糖生成和利用增加。胰岛素浓度也升高。然而，暴露2小时后，氟烷降低了葡萄糖生成和利用，这通过[5-³H]-和[U-¹⁴C]-葡萄糖测定，增加了血浆胰岛素浓度并降低了肝脏糖原浓度，也就是说它加剧了大鼠中已知的损伤效应，包括胰岛素抵抗。高血糖并未加重。