Heston L L, Mastri A R
J Gerontol. 1982 Jul;37(4):422-4. doi: 10.1093/geronj/37.4.422.
The ages at onset of illness for 39 cases of Pick's and 201 cases of Alzheimer's dementia from two series of unselected cases are presented and analyzed. The frequency of Pick's disease peaks in the sixth decade of life and then decreases, whereas Alzheimer's dementia increases steadily through adult life. At least to age 70 years Pick's and other disorders that cannot reliably be separated from Alzheimer's dementia except by autopsy comprise a significant proportion of dementias. Neuropathological diagnoses are essential for most research in dementing illnesses.
本文呈现并分析了两组未经筛选病例中39例皮克病患者和201例阿尔茨海默病痴呆患者的发病年龄。皮克病的发病频率在60岁时达到峰值，随后下降，而阿尔茨海默病痴呆在成年期则持续上升。至少到70岁，除尸检外无法可靠地与阿尔茨海默病痴呆区分开来的皮克病和其他疾病在痴呆症中占相当大的比例。神经病理学诊断对于大多数痴呆症研究至关重要。
