Knopman D S, Christensen K J, Schut L J, Harbaugh R E, Reeder T, Ngo T, Frey W
Department of Neurology, University of Minnesota, MN 55455.
Neurology. 1989 Mar;39(3):362-8. doi: 10.1212/wnl.39.3.362.
To seek improved methods for the diagnosis of Pick's disease, we reviewed imaging studies of four women and two men (ages 48 to 65 years at onset) and psychometric testing of three of them with autopsy or biopsy-proved Pick's. The presence of Pick bodies was required for the diagnosis. Seven patients with biopsy-proved Alzheimer's disease served as a comparison group. In the Pick's patients, CT in five of six showed marked frontal pole or temporal pole atrophy, which clearly differed from the pattern of cerebral atrophy seen in the Alzheimer's patients. Psychometric testing showed performance patterns that tended to differ from those of the Alzheimer's patients in that recent memory was relatively preserved despite marked impairment of executive functions. The distinctive psychometric pattern in the Pick's patients was evanescent, however. Thus, there were imaging and psychometric findings of potential diagnostic value for Pick's disease, but, for different reasons, they were imperfect.
为寻求改进的皮克病诊断方法，我们回顾了4名女性和2名男性（发病时年龄为48至65岁）的影像学研究，并对其中3名经尸检或活检证实为皮克病的患者进行了心理测量测试。诊断需要有皮克小体存在。7例经活检证实为阿尔茨海默病的患者作为对照组。在皮克病患者中，6例中有5例的CT显示明显的额极或颞极萎缩，这与阿尔茨海默病患者的脑萎缩模式明显不同。心理测量测试显示，其表现模式往往与阿尔茨海默病患者不同，即尽管执行功能明显受损，但近期记忆相对保留。然而，皮克病患者独特的心理测量模式是短暂的。因此，有对皮克病具有潜在诊断价值的影像学和心理测量结果，但由于不同原因，它们并不完美。
