Prockop D J
J Invest Dermatol. 1982 Jul;79 Suppl 1:3s-6s. doi: 10.1111/1523-1747.ep12544593.
We now have an impressive amount of information about several steps in the synthesis of type I collagen fibers by skin fibroblasts: (a) the transcription of the genes for pro alpha 1(I) and pro alpha 2(I) polypeptide chains; (b) the processing of the initial RNA transcripts of the genes to mature mRNAs; (c) translation of the mRNAs to prepro alpha 1(I) and prepro alpha 2(I) chains; (d) processing of the prepro alpha 1(I) and prepro alpha 2(I) chains to procollagen; and (e) the further processing of procollagen in collagen fibers. The speed with which we are currently developing this information about collagen and comparable information about other constituents of skin suggests that skin may well be the first human organ which we fully understand.
我们现在已经掌握了关于皮肤成纤维细胞合成I型胶原纤维若干步骤的大量信息：（a）前α1（I）和前α2（I）多肽链基因的转录；（b）基因的初始RNA转录本加工成成熟mRNA；（c）mRNA翻译成前原α1（I）和前原α2（I）链；（d）前原α1（I）和前原α2（I）链加工成前胶原；以及（e）前胶原在胶原纤维中的进一步加工。我们目前获取有关胶原蛋白的这些信息以及有关皮肤其他成分的类似信息的速度表明，皮肤很可能是我们完全了解的首个人体器官。
