Karasawa T, Hayano Y, Imai N
Nihon Sanka Fujinka Gakkai Zasshi. 1982 May;34(5):599-608.
Blood viscosity, a blood flow volume determinant, is one of the primary indicators of the state of pregnancy. The viscosity of peripheral veins was measured using a cone-plate viscometer (share rate 150 sec-1, 375 sec-1) and the results were utilized in comparisons between control and experimental groups to determine their importance to pre-eclamptic patients. Compared with values of 11 non-pregnant subjects (3.614 cp), 165 normal pregnancy cases had lower measurements during the entire term of pregnancy. The viscosity of these normal pregnant subjects decreased up to the 24th week, and increased thereafter. It is hypothesized that this results from the increased plasma volume of pregnant women. In severe pre-eclamptic subjects (3.508 cp), viscosity was significantly higher than in normal pregnancy cases. The natural decrease in peripheral blood flow resulting from elevated viscosity threatens the lives of both mother and fetus. Further analysis of clinical symptoms placed these 31 preeclamptic subjects in the conventional categories of hypertensive, proteinuric, and edematic. Viscosity measurements were highest for hypertensive (4.0059 cp), and lowest for edematic (2.7615 cp) and of intermediate value for proteinuric (3.2122 cp). To normalize these viscosities, the administration of dextran infusion therapy to hypertensive subjects and short-term furosemide therapy to edematic subjects was undertaken and brought considerable beneficial results.
血液粘度是血流量的决定因素之一，是孕期状态的主要指标之一。使用锥板式粘度计（切变率150秒-1、375秒-1）测量外周静脉粘度，并将结果用于对照组和实验组的比较，以确定其对先兆子痫患者的重要性。与11名非孕受试者的值（3.614厘泊）相比，165例正常妊娠病例在整个孕期的测量值较低。这些正常妊娠受试者的粘度在第24周前下降，此后上升。据推测，这是由于孕妇血浆量增加所致。在重度先兆子痫受试者中（3.508厘泊），粘度显著高于正常妊娠病例。粘度升高导致外周血流量自然减少，威胁着母亲和胎儿的生命。对临床症状的进一步分析将这31例先兆子痫受试者归入高血压、蛋白尿和水肿的传统类别。高血压患者的粘度测量值最高（4.0059厘泊），水肿患者最低（2.7615厘泊），蛋白尿患者为中间值（3.2122厘泊）。为使这些粘度正常化，对高血压患者进行了右旋糖酐输注治疗，对水肿患者进行了短期速尿治疗，并取得了相当可观的有益效果。
