Kaibara M, Marumoto Y, Taniguchi I, Kobayashi T
Nihon Sanka Fujinka Gakkai Zasshi. 1981 Aug;33(8):1173-9.
The flow property of blood, the blood viscosity was measured under such gynecological conditions that were potentially hypercoagulable: in the post-operative state for myoma uteri corporis, in the use of oral contraceptives and in the advanced stage of malignant uterine and ovarian tumors. The viscosity was measured at a shear rate of 0.989 sec-1 and at 37 degrees C. Blood viscosity after operation rose to 15.6 +/- 3.7 cp (mean +/- SD), which was significantly higher than that of pre-operative state (12.4 +/- 3.7 cp). This was due to increased hematocrit and fibrinogen levels. The viscosity returned to preoperative level on the 3rd day of post-operation. The blood viscosity of users of oral contraceptives was 15.1 +/- 2.7 cp, not being significantly higher than that of control women (13.4 +/- 2.8 cp). The blood viscosity of patients suffered from malignant tumors was 10.5 +/- 2.0 cp and was significantly lower than that of control. Comparison of viscosity at the same hematocrits revealed, however, that the viscosity of patients of malignant tumors was significantly higher than that of control. Such rheological characteristics in the patients of malignant tumors were due to decreased hematocrit and markedly increased fibrinogen levels. It was suggested that dehydration and infection should be avoided to prevent thrombus formation in the gynecological patients with potentially hypercoagulable state.
在诸如子宫肌瘤术后、使用口服避孕药以及子宫和卵巢恶性肿瘤晚期等具有潜在高凝状态的妇科情况下，对血液的流动特性即血液粘度进行了测量。粘度是在剪切速率为0.989秒⁻¹且温度为37摄氏度的条件下测量的。术后血液粘度升至15.6±3.7厘泊（平均值±标准差），显著高于术前状态（12.4±3.7厘泊）。这是由于血细胞比容和纤维蛋白原水平升高所致。术后第3天粘度恢复到术前水平。口服避孕药使用者的血液粘度为15.1±2.7厘泊，显著高于对照女性（13.4±2.8厘泊）。患有恶性肿瘤患者的血液粘度为10.5±2.0厘泊，显著低于对照组。然而，在相同血细胞比容下粘度的比较显示，恶性肿瘤患者的粘度显著高于对照组。恶性肿瘤患者的这种流变学特征是由于血细胞比容降低和纤维蛋白原水平明显升高所致。建议在具有潜在高凝状态的妇科患者中应避免脱水和感染以预防血栓形成。
