Szutowicz A, Srere P A, Allen C N, Crawford I L
J Neurochem. 1982 Aug;39(2):458-63. doi: 10.1111/j.1471-4159.1982.tb03967.x.
Electrolytic lesions made in the medial septum of the rat brain caused an 80% decrease in the activity of choline acetyltransferase and a 33% reduction in ATP-citrate lyase activity in the synaptosomal fraction from the hippocampus. Decreases in the activities of the two enzymes in the cytosol (S3) fraction were 70 and 13%, respectively. The activities of pyruvate dehydrogenase, citrate synthase, acetyl-CoA synthase, and carnitine acetyltransferase in crude hippocampal homogenates and in subcellular fractions were not affected by septal lesions. The data indicate that ATP-citrate lyase is linked to the septal-hippocampal pathway and that the enzyme is preferentially located in cholinergic nerve endings that terminate within the hippocampus.
在大鼠脑内侧隔区制造的电解损伤，导致海马突触体部分中胆碱乙酰转移酶的活性降低80%，ATP-柠檬酸裂解酶的活性降低33%。胞质溶胶（S3）部分中这两种酶的活性分别降低了70%和13%。粗制海马匀浆和亚细胞部分中丙酮酸脱氢酶、柠檬酸合酶、乙酰辅酶A合酶和肉碱乙酰转移酶的活性不受隔区损伤的影响。数据表明，ATP-柠檬酸裂解酶与隔区-海马通路相关，且该酶优先位于终止于海马内的胆碱能神经末梢中。
