Southern L L, Baker D H
J Nutr. 1982 Jun;112(6):1220-3. doi: 10.1093/jn/112.6.1220.
An experiment was conducted with young, male, crossbred chicks to investigate the interaction between dietary cobalt, methionine and experimental Eimeria acervulina infection (duodenal coccidiosis). Coccidiosis and dietary cobalt (250 mg/kg) depressed weight gain and efficiency of feed utilization; cobalt toxicity, however, was exacerbated by the coccidial infection, resulting in a depression in performance greater than could be accounted for by the independent additive effect of each entity. Dietary cobalt increased the cobalt concentration of the liver, kidney and gallbladder (with bile); experimental coccidiosis in the absence of excess dietary methionine resulted in a twofold increase in cobalt deposition in the liver and gallbladder. Excess supplemental methionine partially alleviated the decrease in chick performance and the increase in tissue cobalt content caused by dietary cobalt in both healthy and infected chicks, but with a slightly greater efficacy in the coccidiosis-infected chicks.
用年轻的雄性杂交雏鸡进行了一项实验，以研究日粮钴、蛋氨酸与实验性堆型艾美耳球虫感染（十二指肠球虫病）之间的相互作用。球虫病和日粮钴（250毫克/千克）会降低体重增加和饲料利用效率；然而，球虫感染会加剧钴中毒，导致生产性能下降幅度大于各因素独立相加效应所能解释的程度。日粮钴会增加肝脏、肾脏和胆囊（含胆汁）中的钴浓度；在没有过量日粮蛋氨酸的情况下，实验性球虫病会导致肝脏和胆囊中的钴沉积增加两倍。过量补充蛋氨酸部分缓解了健康雏鸡和感染雏鸡因日粮钴导致的雏鸡生产性能下降和组织钴含量增加的问题，但在感染球虫病的雏鸡中效果稍好。
