Czarnecki G L, Baker D H
Poult Sci. 1982 Mar;61(3):516-23. doi: 10.3382/ps.0610516.
A series of experiments was conducted with crossbred chicks to determine the effects of L-cysteine, copper, and coccidiosis on roxarsone toxicity. Levels of roxarsone in excess of 50 mg/kg depressed performance and increased kidney arsenic concentration. L-cysteine x HCl x H2O (59%) increased rate and efficiency of gain when added to the basal diet, but depressed performance, increased kidney arsenic concentration, and enhanced mortality when added to diets containing toxic levels of roxarsone (200 mg/kg or higher). Moreover, excess copper (500 mg/kg) partially alleviated the gain/feed depression due to the combination of cysteine and roxarsone. Cysteine, in fact, increased feed efficiency in birds fed excess copper in the absence of roxarsone. Eimeria acervulina infection (duodenal coccidiosis) depressed gain and feed efficiency. The depression in feed efficiency was more severe in the presence of roxarsone (50 or 300 mg/kg). In the absence of coccidiosis, 50 mg/kg roxarsone slightly increased gain/feed ratio.
用杂交雏鸡进行了一系列实验，以确定L-半胱氨酸、铜和球虫病对洛克沙胂毒性的影响。超过50毫克/千克的洛克沙胂水平会降低生产性能并增加肾脏砷浓度。当添加到基础日粮中时，L-半胱氨酸盐酸盐一水合物（59%）可提高生长速度和效率，但添加到含有毒性水平洛克沙胂（200毫克/千克或更高）的日粮中时，会降低生产性能、增加肾脏砷浓度并提高死亡率。此外，过量的铜（500毫克/千克）部分缓解了由于半胱氨酸和洛克沙胂组合导致的增重/采食量下降。事实上，在没有洛克沙胂的情况下，半胱氨酸提高了饲喂过量铜的鸡的饲料效率。堆型艾美耳球虫感染（十二指肠球虫病）降低了增重和饲料效率。在存在洛克沙胂（50或300毫克/千克）的情况下，饲料效率的下降更为严重。在没有球虫病的情况下，50毫克/千克的洛克沙胂略微提高了增重/饲料比。
