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Effects of inducers and inhibitors of cytochrome P-450-linked monooxygenases on the toxicity, in vitro metabolism and in vivo irreversible binding of 2-methylnaphthalene in mice.

作者信息

Griffin K A, Johnson C B, Breger R K, Franklin R B

出版信息

J Pharmacol Exp Ther. 1982 Jun;221(3):517-24.

PMID:7086669
Abstract
摘要

相似文献

1
Effects of inducers and inhibitors of cytochrome P-450-linked monooxygenases on the toxicity, in vitro metabolism and in vivo irreversible binding of 2-methylnaphthalene in mice.细胞色素P-450连接的单加氧酶诱导剂和抑制剂对小鼠体内2-甲基萘的毒性、体外代谢及体内不可逆结合的影响。
J Pharmacol Exp Ther. 1982 Jun;221(3):517-24.
2
The induction of hepatic cytochrome P-450 in C57 BL/10 and DBA/2 mice by isosafrole and piperonyl butoxide. A comparative study with other inducing agents.异黄樟素和胡椒基丁醚对C57 BL/10和DBA/2小鼠肝细胞色素P-450的诱导作用。与其他诱导剂的比较研究。
Chem Biol Interact. 1980 Aug;31(2):189-201. doi: 10.1016/0009-2797(80)90005-8.
3
The relative ethylumbelliferone dealkylase activity characterizing the effect of different inducers on the hydroxylase system in the liver microsomes of female mice.表征不同诱导剂对雌性小鼠肝脏微粒体羟化酶系统作用的相对乙基伞形酮脱烷基酶活性。
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Effects of phenobarbital and methylcholanthrene on hepatic mixed-function-oxidase activities in hamsters.苯巴比妥和甲基胆蒽对仓鼠肝脏混合功能氧化酶活性的影响。
J Environ Pathol Toxicol. 1979 Jan-Feb;2(3):613-23.
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Induction of the drug-metabolizing enzymes.药物代谢酶的诱导
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Acute inhibition of oxidative drug metabolism by propoxyphene (Darvon).丙氧芬（达尔丰）对氧化药物代谢的急性抑制作用。
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Effect of microsomal preparations and induction on cytochrome P-450-dependent monooxygenases in fetal and neonatal rat liver.
Biochem Pharmacol. 1979 Jul 1;28(13):2057-63. doi: 10.1016/0006-2952(79)90224-7.
9
Hepatic and pulmonary microsomal metabolism of naphthalene to glutathione adducts: factors affecting the relative rates of conjugate formation.萘在肝脏和肺微粒体中代谢生成谷胱甘肽加合物：影响共轭物形成相对速率的因素。
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Protection and potentiation of MPTP-induced toxicity by cytochrome P-450 inhibitors and inducer: in vitro studies with brain slices.细胞色素P-450抑制剂和诱导剂对MPTP诱导毒性的保护和增强作用：脑片的体外研究
Brain Res. 1991 Aug 2;555(2):239-44. doi: 10.1016/0006-8993(91)90347-x.

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1
Toxicity and metabolism of methylnaphthalenes: comparison with naphthalene and 1-nitronaphthalene.甲基萘的毒性与代谢：与萘及1-硝基萘的比较
Toxicology. 2009 Jun 16;260(1-3):16-27. doi: 10.1016/j.tox.2009.03.002. Epub 2009 Mar 18.