Vonvoigtlander P F, Kolaja G J, Block E M
J Pharmacol Exp Ther. 1982 Jul;222(1):282-6.
Within a few days of dosing with various structurally unrelated antidepressants, young Fischer 344 rats display punctate lesions on the posterior surface of the cornea. Similar lesions are not seen after treatment with stimulants, an anticholinergic, a serotonin uptake blocker or an alpha adrenergic antagonist. These lesions are peculiar to the Fischer strain; four other strains displayed no such effects. Within the Fischer strain, sensitivity to the lesion-inducing effects of antidepressants is progressively lost with increasing age and adults are insensitive. Examination of the corneal lesions with transmission and scanning electron microscopy revealed that the lesion involved focal eruptions of the endothelium containing fibroblasts, necrotic cells, collagen and mineralized deposits. The latter were confirmed by energy-dispersive X-ray analysis to contain calcium. Thus the reported corneal lesions are unusual in their morphology as well as in their strain, age and drug specificity.
在用各种结构不相关的抗抑郁药给药后的几天内，幼年Fischer 344大鼠的角膜后表面会出现点状病变。用兴奋剂、抗胆碱能药、5-羟色胺摄取阻滞剂或α-肾上腺素能拮抗剂治疗后未观察到类似病变。这些病变是Fischer品系特有的；其他四个品系未表现出此类效应。在Fischer品系中，随着年龄增长，对抗抑郁药致病变效应的敏感性逐渐丧失，成年大鼠不敏感。用透射电子显微镜和扫描电子显微镜检查角膜病变发现，病变涉及含有成纤维细胞、坏死细胞、胶原蛋白和矿化沉积物的内皮细胞局灶性喷发。能量色散X射线分析证实后者含有钙。因此，所报道的角膜病变在形态以及品系、年龄和药物特异性方面都很不寻常。
