Clohisy D R, Quintanilla A P, Gibson T P
J Pharmacol Exp Ther. 1982 Jul;222(1):49-51.
The effect of an infusion of quinidine, 180 micrograms/kg/Min (base) on the fractional clearance of digoxin (CDIG/Cin) was studied in saline volume-expanded dogs given a constant infusion of digoxin of either 0.0067 micrograms/kg/min (low dose) or 0.120 micrograms/kg/min (high dose). CDIG/CIN decreased 28% from 1.42 +/- 0.36 during control periods to 1.01 +/- 0.03 (P less than .05) with quinidine in dogs given the low dose. In dogs given the high dose of digoxin, CDIG/CIN decreased 22% from 0.76 +/- 0.17 to 0.59 +/- 0.05 (p less than .05) with quinidine. It is concluded that quinidine reduces CDIG/CIN. High doses of digoxin also reduce CDIG/CIN. Inasmuch as quinidine reduces CDIG/CIN to the same extent in the presence of low or high dose digoxin, the effect of quinidine would appear to be mediated through a mechanism different from that of digoxin.
在给予生理盐水扩容的犬中，以180微克/千克/分钟（碱基）的速度输注奎尼丁，对持续输注低剂量（0.0067微克/千克/分钟）或高剂量（0.120微克/千克/分钟）地高辛时地高辛的分数清除率（CDIG/Cin）的影响进行了研究。在给予低剂量地高辛的犬中，使用奎尼丁时，CDIG/CIN从对照期的1.42±0.36下降了28%，至1.01±0.03（P<0.05）。在给予高剂量地高辛的犬中，使用奎尼丁时，CDIG/CIN从0.76±0.17下降了22%，至0.59±0.05（P<0.05）。结论是奎尼丁降低CDIG/CIN。高剂量地高辛也降低CDIG/CIN。由于在低剂量或高剂量地高辛存在的情况下，奎尼丁降低CDIG/CIN的程度相同，奎尼丁的作用似乎是通过与地高辛不同的机制介导的。
