Gibson T P, Quintanilla A
J Lab Clin Med. 1980 Dec;96(6):1062-70.
The effect of left renal artery infusion of quinidine, 37.5 microgram (base)/kg/min on the renal clearance of ultrafilterable digoxin was studied in eight dogs given 0.06 mg/kg digoxin 24 hr previously. Digoxin was measured by 125I RIA, whose specificity was confirmed by HPLC. Within 15 min of the start of the infusion, the digoxin clearance decreased on the left 7.3 +/- 5.8 ml/min and on the right 6.1 +/- 6.4 ml/min, p < 0.02 and 0.05, respectively, compared to control. Quinidine infusion did not alter Cin. CDIG returned toward prequinidine infusion values after the infusion was stopped. We conclude that quinidine has a prompt and direct effect on the renal clearance of digoxin.
在8只于24小时前给予0.06mg/kg地高辛的犬中，研究了以37.5微克（碱基）/千克/分钟的速度向左肾动脉输注奎尼丁对可超滤性地高辛肾清除率的影响。地高辛通过125I放射免疫分析法测定，其特异性经高效液相色谱法确认。在输注开始后的15分钟内，与对照组相比，左肾地高辛清除率下降了7.3±5.8毫升/分钟，右肾下降了6.1±6.4毫升/分钟，p值分别<0.02和0.05。奎尼丁输注未改变菊粉清除率。输注停止后，地高辛清除率恢复到输注奎尼丁前的值。我们得出结论，奎尼丁对肾地高辛清除率有迅速而直接的影响。
