反式-2-(2,5-二甲氧基-4-甲基苯基)环丙胺的同分异构环丙基环甲基化同系物，一种致幻剂类似物。

Isomeric cyclopropyl ring-methylated homologues of trans-2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine, an hallucinogen analogue.

作者信息

Jacob J N, Nichols D E

出版信息

J Med Chem. 1982 May;25(5):526-30. doi: 10.1021/jm00347a009.

Abstract

The hallucinogen analogue trans-2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine was modified by adding a 3-methyl group, either cis or trans with respect to the amino group. These two isomeric cyclopropyl ring-methylated compounds were then tested for activity in the mouse ear-scratch assay and for a contractile effect in the rat fundus preparation. Neither compound was found to possess appreciable activity when compared to the nonmethylated parent, in either assay.

摘要

通过添加一个相对于氨基为顺式或反式的3-甲基，对致幻剂类似物反式-2-(2,5-二甲氧基-4-甲基苯基)环丙胺进行了修饰。然后在小鼠耳部抓挠试验中测试了这两种异构的环丙基环甲基化化合物的活性，并在大鼠胃底制备中测试了它们的收缩作用。在这两种试验中，与未甲基化的母体相比，未发现这两种化合物具有明显的活性。