1-（2,4,5-三甲氧基苯基）-2-氨基丙烷的单甲硫基类似物

Monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane.

作者信息

Jacob P, Anderson G, Meshul C K, Shulgin A T, Castagnoli N

出版信息

J Med Chem. 1977 Oct;20(10):1235-9. doi: 10.1021/jm00220a001.

Abstract

Regiospecific syntheses of the three monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane are described. The three isomeric amines were evaluated for potential psychotomimetic potency using the rabbit hyperthermia assay. Enantiomeric compositions and time-concentration curves in rat brains were determined following intraperitoneal administration of each compound. The biological data are contrasted with the corresponding results obtained with the potent human psychotogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM).

摘要

本文描述了1-(2,4,5-三甲氧基苯基)-2-氨基丙烷的三种单甲硫基类似物的区域特异性合成。使用兔体温过高试验评估了这三种异构胺的潜在拟精神病效力。在腹腔注射每种化合物后，测定了大鼠脑中的对映体组成和时间-浓度曲线。将生物学数据与强效人类精神致幻剂1-(2,5-二甲氧基-4-甲基苯基)-2-氨基丙烷（DOM）获得的相应结果进行了对比。