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博来霉素、甲氨蝶呤及远距钴照射联合治疗口腔癌(作者译)

[Combination therapy by bleomycin, methotrexate, and telecobalt irradiation in carcinoma of the oral cavity (author's transl)].

作者信息

Bitter K

出版信息

Strahlentherapie. 1977 Jul;153(7):449-55.

PMID:70869
Abstract

20 patients with advanced carcinomas of the oral cavity (T3NxMo) were treated at the same time with the cytostatic drugs bleomycin and methotrexate as well as with a cobalt-60-irradiation. 14 of them are tumor free after an observation period of one half to two and a half years. Among them were 4 recurrences that had to be treated surgically. 1 patient is living with a residual tumor which cannot be further treated. 5 patients died of the tumor or of other causes. The survival rate, which is 80% after 1 year, is, as a tentative result, higher than could be attained by other therapeutic measures.

摘要

20例口腔晚期癌(T3NxMo)患者同时接受了细胞抑制药物博来霉素和甲氨蝶呤治疗以及钴-60照射。经过半年到两年半的观察期后,其中14例患者无肿瘤。其中有4例复发,必须接受手术治疗。1例患者残留肿瘤无法进一步治疗。5例患者死于肿瘤或其他原因。作为初步结果,1年后的生存率为80%,高于其他治疗措施所能达到的生存率。

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