Bitter K
J Maxillofac Surg. 1977 Feb;5(1):75-81. doi: 10.1016/s0301-0503(77)80080-5.
20 patients suffering from advanced oral carcinoma (T3NXMO) were treated simultaneously with the cytostatics Bleomycin and Methotrexate and Telecobalt-radiation. 14 of them (70%) showed complete remission. Four relapses were treated by surgery. These patients are still alive and tumour-free. One patient with a tumour is also still alive. Five died of their tumours or other causes. As a preliminary result, overall survival of about 80% after the first year seems to be much higher than with other therapeutic procedures.
20例晚期口腔癌(T3NXMO)患者同时接受了细胞抑制剂博来霉素和甲氨蝶呤以及远距离钴放疗。其中14例(70%)显示完全缓解。4例复发患者接受了手术治疗。这些患者仍然存活且无肿瘤。1例有肿瘤的患者也仍然存活。5例死于肿瘤或其他原因。作为初步结果,第一年的总生存率约为80%,似乎远高于其他治疗方法。