睾酮给药对新生期雄激素化（NA）雌性大鼠血浆催乳素水平的影响。

The influence of testosterone administration on plasma prolactin levels in the neonatally androgenized (NA) female rat.

作者信息

Gala R R, Haisenleder D J

出版信息

Life Sci. 1982 Apr 5;30(14):1201-4. doi: 10.1016/0024-3205(82)90663-4.

Abstract

Neonatally androgenized (NA) female rats were ovariectomized (OVX) as adults and given 1 mg of testosterone propionate/day for 7 days and the plasma prolactin (PRL) pattern compared with NA intact animals and normal OVX animals given estrogen or TP. NA intact animals had elevated basal (morning values) and an attenuated afternoon surge when compared to normal estrogen-treated animals. Testosterone administration to normal animals induced an afternoon surge similar to that of normal estrogen-treated animals but the magnitude of the surge was less. Testosterone given to NA-OVX animals had little effect on either morning or afternoon PRL levels. The results suggest that in the NA rat the brain region involved in the conversion of testosterone to estrogen may be altered by neonatal androgen exposure.

摘要

新生期经雄激素化处理（NA）的雌性大鼠成年后进行卵巢切除（OVX），并连续7天每天给予1毫克丙酸睾酮，然后将其血浆催乳素（PRL）模式与NA完整动物以及给予雌激素或丙酸睾酮的正常OVX动物进行比较。与正常雌激素处理的动物相比，NA完整动物的基础水平（早晨值）升高，下午的高峰减弱。对正常动物给予睾酮可诱导出与正常雌激素处理动物相似的下午高峰，但高峰幅度较小。给予NA-OVX动物睾酮对上午或下午的PRL水平几乎没有影响。结果表明，在NA大鼠中，参与睾酮向雌激素转化的脑区可能因新生期雄激素暴露而发生改变。