Tonkopiĭ V D, Ardab'eva T V
Biull Eksp Biol Med. 1978 Oct;86(10):441-4.
The effect of galanthamine, tacrine, and oxazyl (ambenomum) on human red cells acetylcholinesterase phosphorylation by armine and Gd-42 (o-ethyl-s-beta-ethylthioethyl ester of methylthiophosphinic acid) was studied. In the presence of galanthamine phosphororganic inhibitors interacted only with the active center of the enzyme, the anionic site of which was not occupied by the reversible inhibitor. Tacrine and oxazyl decreased the reactivity of the free enzyme and the rate of its phosphorylation.
研究了加兰他敏、他克林和奥沙唑（氨苯那明）对人红细胞乙酰胆碱酯酶被氨胺和Gd-42（甲基硫代次膦酸的邻乙基-s-β-乙硫基乙酯）磷酸化的影响。在加兰他敏存在的情况下，有机磷抑制剂仅与酶的活性中心相互作用，其阴离子部位未被可逆抑制剂占据。他克林和奥沙唑降低了游离酶的反应性及其磷酸化速率。
