Orn A, Håkansson E M, Gidlund M, Ramstedt U, Axberg I, Wigzell H, Lundin L G
Scand J Immunol. 1982 Mar;15(3):305-10. doi: 10.1111/j.1365-3083.1982.tb00653.x.
The impact of five pigment mutations in the mouse on natural killer (NK) activity was examined in inbred strains congenic for the respective mutation. Whereas the nature of pigmentation disorder was similar in the five mutant strains (beige, pallid, reduced pigmentation, pale ear, and sepia), all mutations except sepia also led to a significant change in lysosomal enzyme activities in the kidney. A significant reduction in NK activity was observed in the four strains with lysosomal impact, whereas homozygous sepia mice displayed normal NK activity. The pigment mutations analysed are located on different chromosomes and fail to cross-interact negatively with each other in the heterozygous mice. This would indicate that pigment mutations with a parallel impact on lysosomal enzyme activities probably always result in a reduction in natural killer cell activity.
在各自突变的近交系同源小鼠中，研究了小鼠的五种色素突变对自然杀伤（NK）活性的影响。尽管这五个突变品系（米色、苍白、色素沉着减少、耳苍白和乌贼墨色）的色素沉着紊乱性质相似，但除乌贼墨色外的所有突变也导致肾脏溶酶体酶活性发生显著变化。在有溶酶体影响的四个品系中观察到NK活性显著降低，而纯合乌贼墨色小鼠表现出正常的NK活性。所分析的色素突变位于不同染色体上，在杂合小鼠中不会相互产生负向交叉作用。这表明对溶酶体酶活性有平行影响的色素突变可能总是导致自然杀伤细胞活性降低。
