Starkey J R, Prieur D J, Ristow S S
Experientia. 1983 Mar 15;39(3):308-10. doi: 10.1007/BF01955321.
Fawn-hooded (FH) rats were shown to lack the genetically conditioned defect of natural killer (NK) activity hypothesized to be present by analogy with the Chediak-Higashi syndrome (CHS) in mice and human beings. In 4-h 51Cr release assays, splenic NK cells from FH rats killed YAC-1, RL male l and G1-TC tumor targets without deficiency based upon comparison with cells from BD-IV, BD-IX and NBR inbred rat strains. Progeny of BD X FH F1 rats backcrossed to FH failed to reveal a correlation of reduced NK activity and dilute coat color. From these, and other data presented, it is concluded that despite similarities in coat color dilution and platelet storage pool deficiency. FH rats do not closely resemble CHS mice or human beings in having deficient NK activity and cannot be considered the rat homolog of the CHS.
鹿毛色（FH）大鼠被证明不存在自然杀伤（NK）活性的基因决定缺陷，该缺陷被假定通过与小鼠和人类的切-东综合征（CHS）类比而存在。在4小时的51Cr释放试验中，与BD-IV、BD-IX和NBR近交系大鼠的细胞相比，FH大鼠的脾NK细胞杀伤YAC-1、RL雄性1和G1-TC肿瘤靶标的能力没有缺陷。BD X FH F1大鼠与FH回交的后代未能揭示NK活性降低与毛色变淡之间的相关性。从这些以及所呈现的其他数据可以得出结论，尽管在毛色变淡和血小板储存池缺陷方面存在相似之处，但FH大鼠在NK活性缺陷方面与CHS小鼠或人类并不十分相似，不能被视为CHS的大鼠同源物。
