An enzymatic system for removing heparin in extracorporeal therapy.
作者信息
Langer R, Linhardt R J, Hoffberg S, Larsen A K, Cooney C L, Tapper D, Klein M
出版信息
Science. 1982 Jul 16;217(4556):261-3. doi: 10.1126/science.7089564.
PMID:7089564
Abstract
The need to fully heparinize patients undergoing extracorporeal therapy often leads to hemorrhagic complications. To enable heparinization of only the extracorporeal circuit, a blood filter containing immobilized heparinase was developed. This filter degraded 99 percent of heparin's anticoagulant activity within minutes in both canine and human blood.
摘要
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