游离甲状腺素还是游离甲状腺素指数？
Free thyroxine or free thyroxine index?
作者信息
Miller J L, Smith J
出版信息
S Afr Med J. 1982 Jun 12;61(24):921-2.
Free thyroxine (FT4) values determined by direct radio-immunoassay and the free thyroxine index (FTI) determined by indirect calculation were compared in 431 consecutive sera from patients with suspected thyroid dysfunction . Sensitivity and specificity were similar for both tests in the thyrotoxic, hypothyroid and euthyroid ranges with appropriate thyroid-binding globulin (TBG) concentrations. However, FT4 was superior to FTI in the euthyroid group with high concentrations of TBG, FT4 is therefore a useful alternative to FTI as a screening test for thyroid dysfunction, and is likely to be a better discriminator of thyroid status in patients with high TBG levels.
对431例疑似甲状腺功能障碍患者的连续血清样本，比较了直接放射免疫分析法测定的游离甲状腺素（FT4）值和间接计算得出的游离甲状腺素指数（FTI）。在甲状腺毒症、甲状腺功能减退和甲状腺功能正常范围内，当甲状腺结合球蛋白（TBG）浓度适当时，两种检测方法的敏感性和特异性相似。然而，在TBG浓度高的甲状腺功能正常组中，FT4优于FTI。因此，FT4可作为FTI的有效替代方法用于甲状腺功能障碍的筛查，并且在TBG水平高的患者中可能是更好的甲状腺状态判别指标。
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