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1
Further evidence for the prevention by guanethidine of noradrenaline efflux from rabbit ventricular slices induced by a low external sodium concentration.胍乙啶预防低细胞外钠浓度诱导的兔心室肌切片去甲肾上腺素外流的进一步证据。
Br J Pharmacol. 1978 Oct;64(2):163-5. doi: 10.1111/j.1476-5381.1978.tb17285.x.
2
Prevention by guanethidine analogues of output of noradrenaline induced by sodium reduction in rabbit ventricular slices.胍乙啶类似物对兔心室切片中因钠减少诱导的去甲肾上腺素释放的预防作用
Br J Pharmacol. 1978 Sep;64(1):37-45. doi: 10.1111/j.1476-5381.1978.tb08638.x.
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Effects of calcium and guanethidine on noradrenaline output induced by sodium reduction in rabbit atria.钙和胍乙啶对兔心房钠减少诱导的去甲肾上腺素释放的影响。
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Extra-vesicular binding of noradrenaline and guanethidine in the adrenergic neurones of the rat heart: a proposed site of action of adrenergic neurone blocking agents.去甲肾上腺素和胍乙啶在大鼠心脏肾上腺素能神经元中的囊泡外结合：肾上腺素能神经元阻断剂的一个假定作用位点。
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5
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Br J Pharmacol. 1978 May;63(1):17-23. doi: 10.1111/j.1476-5381.1978.tb07769.x.
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Inhibition of sympathetic noradrenergic transmission by guanabenz and guanethidine in rat isolated mesenteric artery: involvement of neuronal potassium channels.胍那苄和胍乙啶对大鼠离体肠系膜动脉交感去甲肾上腺素能传递的抑制作用：神经元钾通道的参与
Pharmacol Res. 1996 Mar;33(3):171-80. doi: 10.1006/phrs.1996.0024.
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Factors affecting the action of guanethidine on adrenergic neurones.影响胍乙啶对肾上腺素能神经元作用的因素。
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A study of the sympathomimetic action of guanethidine on the isolated anococcygeus muscle of the rat.胍乙啶对大鼠离体尾骨肌的拟交感神经作用研究。
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Mode of action of guanethidine on adrenergic neurons and its dependence on sodium.
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引用本文的文献

1
Guanethidine after twenty years: a pharmacologist's perspective.二十年后的胍乙啶：一位药理学家的视角
Br J Clin Pharmacol. 1982 Jan;13(1):35-44. doi: 10.1111/j.1365-2125.1982.tb01334.x.

本文引用的文献

1
ADRENERGIC NEURONE BLOCKING AGENTS.肾上腺素能神经元阻断剂
Annu Rev Pharmacol. 1965;5:183-212. doi: 10.1146/annurev.pa.05.040165.001151.
2
A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.一项关于影响用于儿茶酚胺分析的氧化铝 - 三羟基吲哚法的因素的研究。
J Pharmacol Exp Ther. 1962 Dec;138:360-75.
3
Factors affecting the action of guanethidine on adrenergic neurones.影响胍乙啶对肾上腺素能神经元作用的因素。
Br J Pharmacol. 1971 Jul;42(3):352-63. doi: 10.1111/j.1476-5381.1971.tb07119.x.
4
Mode of action of guanethidine on adrenergic neurons and its dependence on sodium.
Jpn J Pharmacol. 1974 Apr;24(2):307-18. doi: 10.1254/jjp.24.307.
5
A new guanidine derivative: dissociation of the adrenergic neuron blocking activity from local anesthetic activity.一种新的胍衍生物：肾上腺素能神经元阻滞活性与局部麻醉活性的分离。
Jpn J Pharmacol. 1976 Jun;26(3):367-75. doi: 10.1254/jjp.26.367.
6
Sodium sensitive active transport of bretylium into adrenergic neurons for the development of blockade in rabbit ileum.溴苄铵通过钠敏感主动转运进入肾上腺素能神经元，用于兔回肠中阻滞作用的产生。
Arch Int Pharmacodyn Ther. 1977 Apr;226(2):235-45.
7
Action of guanethidine on rabbit atrial membranes.胍乙啶对兔心房膜的作用。
Br J Pharmacol. 1978 May;63(1):17-23. doi: 10.1111/j.1476-5381.1978.tb07769.x.

胍乙啶预防低细胞外钠浓度诱导的兔心室肌切片去甲肾上腺素外流的进一步证据。

Further evidence for the prevention by guanethidine of noradrenaline efflux from rabbit ventricular slices induced by a low external sodium concentration.

作者信息

Hosotani T, Misu Y

出版信息

Br J Pharmacol. 1978 Oct;64(2):163-5. doi: 10.1111/j.1476-5381.1978.tb17285.x.

DOI:10.1111/j.1476-5381.1978.tb17285.x
PMID:708988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1668313/
Abstract

When guanethidine was applied to rabbit ventricular slices at 37 degrees C for an initial 30 min incubation period, doses of 4 X 10(-5) and 8 X 10(-5) M irreversibly inhibited increases in efflux of noradrenaline induced by the subsequent reduction of external sodium concentrations to 18 mM. This inhibition was prevented if the temperature was reduced to 0 degrees C during the drug application period. Guanethidine transported into adrenergic nerve endings appears to increase permeability to Na+, thereby leading to the reduction in efflux.

摘要

当将胍乙啶应用于37℃的兔心室切片并进行初始30分钟的孵育期时，4×10⁻⁵和8×10⁻⁵M的剂量不可逆地抑制了随后将细胞外钠浓度降至18mM所诱导的去甲肾上腺素外流增加。如果在药物应用期间将温度降至0℃，这种抑制作用可以被防止。转运到肾上腺素能神经末梢的胍乙啶似乎会增加对Na⁺的通透性，从而导致外流减少。