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The uptake of guanethidine by adrenergic neurones has been studied indirectly by testing the ability of various procedures to prevent or reverse adrenergic neurone blockade in the periarterially stimulated isolated ileum preparation.2. Adrenergic neurone blockade was prevented but not reversed by equilibration with guanethidine (3.3 x 10(-6)M) at low temperatures (10 degrees C), in the absence of sodium or in the presence of tetrodotoxin (0.3 x 10(-6)M) or noradrenaline (1.2 x 10(-3)M).3. Calcium (5 x 10(-2)M) both prevented and, to some extent, reversed the adrenergic neurone blocking action of guanethidine.4. Equilibration with guanethidine in the presence of mersalyl (0.6 x 10(-7)M) or in the absence of potassium or calcium could neither prevent nor reverse adrenergic neurone blockade.

通过测试各种方法预防或逆转动脉周围刺激的离体回肠制剂中肾上腺素能神经元阻滞的能力，间接研究了肾上腺素能神经元对胍乙啶的摄取。
在低温（10℃）下，在无钠或存在河豚毒素（0.3×10⁻⁶M）或去甲肾上腺素（1.2×10⁻³M）的情况下，用胍乙啶（3.3×10⁻⁶M）平衡可预防但不能逆转肾上腺素能神经元阻滞。
钙（5×10⁻²M）既能预防胍乙啶的肾上腺素能神经元阻滞作用，在一定程度上又能逆转该作用。
在存在汞撒利（0.6×10⁻⁷M）或无钾或钙的情况下，用胍乙啶平衡既不能预防也不能逆转肾上腺素能神经元阻滞。

The uptake of guanethidine by adrenergic neurones has been studied indirectly by testing the ability of various procedures to prevent or reverse adrenergic neurone blockade in the periarterially stimulated isolated ileum preparation.2. Adrenergic neurone blockade was prevented but not reversed by equilibration with guanethidine (3.3 x 10(-6)M) at low temperatures (10 degrees C), in the absence of sodium or in the presence of tetrodotoxin (0.3 x 10(-6)M) or noradrenaline (1.2 x 10(-3)M).3. Calcium (5 x 10(-2)M) both prevented and, to some extent, reversed the adrenergic neurone blocking action of guanethidine.4. Equilibration with guanethidine in the presence of mersalyl (0.6 x 10(-7)M) or in the absence of potassium or calcium could neither prevent nor reverse adrenergic neurone blockade.

通过测试各种方法预防或逆转动脉周围刺激的离体回肠制剂中肾上腺素能神经元阻滞的能力，间接研究了肾上腺素能神经元对胍乙啶的摄取。
在低温（10℃）下，在无钠或存在河豚毒素（0.3×10⁻⁶M）或去甲肾上腺素（1.2×10⁻³M）的情况下，用胍乙啶（3.3×10⁻⁶M）平衡可预防但不能逆转肾上腺素能神经元阻滞。
钙（5×10⁻²M）既能预防胍乙啶的肾上腺素能神经元阻滞作用，在一定程度上又能逆转该作用。
在存在汞撒利（0.6×10⁻⁷M）或无钾或钙的情况下，用胍乙啶平衡既不能预防也不能逆转肾上腺素能神经元阻滞。

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