Proust J, Moulias R, Fumeron F, Bekkhoucha F, Busson M, Schmid M, Hors J
Tissue Antigens. 1982 Mar;19(3):168-73. doi: 10.1111/j.1399-0039.1982.tb01436.x.
One hundred fifty-five healthy nonagenarians, 45 men and 100 women, all French Caucasians, were phenotyped for alleles of the A, B, C, DR loci of the HLA complex. The observed HLA antigen frequencies were compared to those of a control series of 133 males and 179 females whose ages ranged from 10 to 50 years. When comparing the total young and elderly series, no significant differences were observed with respect to HLA antigen distribution or heterozygosity at any of the loci. When taking sex difference into account, however, an excess of the Cw1 antigen was found in the group of elderly females (p less than 0.001) and an excess of the Cw7 antigen in the group of elderly males (p less than 0.001). Of particular significance was the fact that Cw7 belonged in this instance to a phenotypic combination (and most probably to the corresponding haplotype) A1/Cw7/B8/DR3 which was found significantly increased in male nonagenarians (p less than 0.001). These results support the hypothesis that certain HLA haplotypes are associated with survival advantage.
155名健康的九十多岁老人（45名男性和100名女性，均为法国白种人）接受了HLA复合体A、B、C、DR位点等位基因的表型分析。将观察到的HLA抗原频率与一个年龄在10至50岁之间的由133名男性和179名女性组成的对照系列的频率进行比较。在比较整个年轻和老年系列时，在任何位点的HLA抗原分布或杂合性方面均未观察到显著差异。然而，考虑到性别差异时，在老年女性组中发现Cw1抗原过量（p小于0.001），在老年男性组中发现Cw7抗原过量（p小于0.001）。特别重要的是，在这种情况下，Cw7属于一种表型组合（很可能属于相应的单倍型）A1/Cw7/B8/DR3，该组合在男性九十多岁老人中显著增加（p小于0.001）。这些结果支持了某些HLA单倍型与生存优势相关的假说。
