喂食六氯苯的雌性大鼠的子代死亡率和母体肺部病理学

Offspring mortality and maternal lung pathology in female rats fed hexachlorobenzene.

作者信息

Kitchin K T, Linder R E, Scotti T M, Walsh D, Curley A O, Svendsgaard D

出版信息

Toxicology. 1982;23(1):33-9. doi: 10.1016/0300-483x(82)90039-7.

Abstract

Female Sprague-Dawley CD rats were fed 0, 60, 80, 100, 120 and 140 ppm hexachlorobenzene (HCB) continuously in the diet and 2 successive litters raised. These doses were selected to range from approximately the no observable effect level to lethality in suckling offspring of treated dams. In the F1a generation, the 21-day mortality was 9.2, 19.8, 30.0, 45.4, 93.1 and 92.6% in offspring of dms fed 0, 60, 80, 100, 120 and 140 ppm HCB, respectively. In the F1b generation, a similar mortality of 18.5, 21.5, 19.5, 45, 100, and 94.1% was observed at these 5 dose levels, respectively. The neonatal lethality observed was related to both maternal dose of HCB and the cumulative lactational exposure. Clinical signs of maternal toxicity were not observed and fertility and fecundity were unaffected. In the lungs of HCB treated dams, increased numbers f intraalveolar foamy histiocytes and hypertrophy and proliferation of the lining endothelial cells of pulmonary venules were observed. These microscopic findings of pulmonary effects of HCB confirmed findings of this laboratory.

摘要

将雌性斯普拉格-道利CD大鼠连续喂食含0、60、80、100、120和140 ppm六氯苯（HCB）的饲料，并饲养两窝连续的幼崽。选择这些剂量是为了涵盖从大致无明显影响水平到经处理母鼠哺乳后代致死率的范围。在F1a代中，喂食0、60、80、100、120和140 ppm HCB的母鼠后代21天死亡率分别为9.2%、19.8%、30.0%、45.4%、93.1%和92.6%。在F1b代中，在这5个剂量水平下分别观察到类似的死亡率，即18.5%、21.5%、19.5%、45%、100%和94.1%。观察到的新生仔鼠致死率与母鼠HCB剂量和累积哺乳期暴露均有关。未观察到母鼠毒性的临床体征，生育能力和繁殖力未受影响。在经HCB处理的母鼠肺中，观察到肺泡内泡沫状组织细胞数量增加以及肺小静脉内衬内皮细胞肥大和增殖。HCB肺部效应的这些微观发现证实了本实验室的发现。