Courtney K D, Andrews J E, Grady M A, Ebron M T
Toxicol Lett. 1984 Aug;22(2):223-8. doi: 10.1016/0378-4274(84)90070-5.
Pregnant CD-1 mice were treated with hexachlorobenzene (HCB) by gavage at doses of 0, 1, 10 and 50 mg HCB/kg body weight on days 6-17 of gestation and studied on day 1 or 21 postpartum (pp). Hearts of the dams and pups were assayed for lactic dehydrogenase (LDH) and creatine kinase (CK) activities and isozyme profiles. LDH and CK activities and CK isozyme profiles were not affected in the dams by HCB treatment, but isozyme LDH-5 was significantly depressed and isozyme LDH-3 significantly increased at the 50 mg/kg dose of HCB on day 1 pp. Hearts of the pups were studied on days 1, 8, 10, 15 and 21 pp. The 50 mg/kg dose level resulted in a statistically significantly increased mortality in the pups. The mortality at the other doses showed a dose-related effect. LDH and CK activities and CK isozyme profiles were not affected by HCB exposure in utero. The only isozyme affected was LDH-5 with a statistically significant increase in the 50 mg/kg dose group on day 21 pp.
妊娠第6至17天，对妊娠的CD-1小鼠经口灌胃给予剂量为0、1、10和50毫克六氯苯（HCB）/千克体重的HCB，并在产后第1天或第21天进行研究。对母鼠和幼鼠的心脏进行乳酸脱氢酶（LDH）和肌酸激酶（CK）活性及同工酶谱分析。HCB处理对母鼠的LDH和CK活性及CK同工酶谱没有影响，但在产后第1天，50毫克/千克剂量的HCB使同工酶LDH-5显著降低，同工酶LDH-3显著增加。在产后第1、8、10、15和21天对幼鼠的心脏进行研究。50毫克/千克剂量水平导致幼鼠死亡率在统计学上显著增加。其他剂量的死亡率呈现剂量相关效应。子宫内接触HCB对LDH和CK活性及CK同工酶谱没有影响。唯一受影响的同工酶是LDH-5，在产后第21天，50毫克/千克剂量组中其含量在统计学上显著增加。
