Skin absorption of aniline from aqueous solutions in man.

The skin absorption of aniline, aniline with 3% water content, and 1 and 2% aqueous aniline solutions was investigated in man. The time of exposure was 30 or 60 min. The absorbed amount of aniline was calculated on the basis of rho-aminophenol excretion in 24-h urine. The rate of aniline absorption from aqueous solutions was approx. 0.20 to 1.22 mg/cm2/h. There was no significant difference between the mean rate of absorption of liquid aniline (3.0 mg/cm2/h) and that with 3% content of water (2.5 mg/cm2/h).