Sher S P, Jensen R D, Bokelman D L
Toxicol Lett. 1982 Apr;11(1-2):103-10. doi: 10.1016/0378-4274(82)90113-8.
The incidence of spontaneous neoplasms in outbred, inbred and F1 hybrid strains was compared using the Charles River-CD rat and mouse, the F344 rat, and B6C3HF1 mouse. These strains are commonly used in carcinogenic studies. Each strain has a consistent pattern of tumor occurrence; testicular, pituitary and lymphoreticular neoplasms are common in F344 rats, mammary and pituitary neoplasms are common in Charles River-CD rats, liver neoplasms are uncommon in CD-1 mice, while hepatic tumors are frequent in male B6C3HF1 mice. There is considerable variation in tumor incidence in individual studies regardless of strain and there appeared to be greater variation in incidence between laboratories using the same strain than in the different laboratories using unlike strains. Therefore, the choice between these strains may be fortuitous or recommended by governmental agencies. Regardless of the strain selected, it is vital to develop sufficient historical tumor data on the strain used at the particular test laboratory.
使用查尔斯河-CD大鼠和小鼠、F344大鼠以及B6C3HF1小鼠，比较了远交、近交和F1杂交品系中自发性肿瘤的发生率。这些品系常用于致癌研究。每个品系都有一致的肿瘤发生模式；睾丸、垂体和淋巴网状肿瘤在F344大鼠中常见，乳腺和垂体肿瘤在查尔斯河-CD大鼠中常见，肝脏肿瘤在CD-1小鼠中不常见，而肝肿瘤在雄性B6C3HF1小鼠中很常见。无论品系如何，个体研究中的肿瘤发生率都有相当大的差异，而且使用同一品系的不同实验室之间的发生率差异似乎比使用不同品系的不同实验室之间的差异更大。因此，在这些品系之间的选择可能是偶然的，或者是由政府机构推荐的。无论选择何种品系，在特定测试实验室中建立所使用品系的充分的历史肿瘤数据至关重要。
