Conti C J, Clapp N, Klein-Szanto A J, Nesnow S, Slaga T J
Carcinogenesis. 1985 Nov;6(11):1649-52. doi: 10.1093/carcin/6.11.1649.
The survival curves and the incidence of spontaneous diseases were studied in a population of SENCAR mice, a stock derived by a selected breeding protocol for enhanced susceptibility to chemical carcinogenesis in the skin. SENCAR mice proved to be as long-lived as other mouse strains or stocks, including one of their parental lines, Charles River CD-1. The most frequently occurring neoplasias in SENCAR mice were lymphoma, myeloid leukemia and reticulum cell sarcoma. Other frequently occurring neoplastic diseases included lung adenomas and carcinoma and mammary gland carcinoma. However, the incidence of these tumors was not higher than the incidence in CD-1 mice or other mouse strains or stocks. A variety of non-neoplastic diseases, both inflammatory and degenerative, were also observed in old mice. The most common were liver, spleen and kidney amyloidosis, pyelonephritis and papillary necrosis. These data indicate that selective breeding for susceptibility to chemical carcinogenesis has not produced a concomitant increase in the incidence of spontaneous neoplastic and non-neoplastic disease.
在一组SENCAR小鼠中研究了生存曲线和自发性疾病的发生率，SENCAR小鼠是通过特定的育种方案培育而来的，该方案旨在增强皮肤对化学致癌作用的易感性。事实证明，SENCAR小鼠与其他小鼠品系或种群一样长寿，包括其亲本系之一查尔斯河CD-1小鼠。SENCAR小鼠中最常见的肿瘤形成是淋巴瘤、髓性白血病和网状细胞肉瘤。其他常见的肿瘤性疾病包括肺腺瘤、肺癌和乳腺癌。然而，这些肿瘤的发生率并不高于CD-1小鼠或其他小鼠品系或种群中的发生率。在老年小鼠中还观察到了多种非肿瘤性疾病，包括炎症性和退行性疾病。最常见的是肝、脾和肾淀粉样变性、肾盂肾炎和乳头坏死。这些数据表明，针对化学致癌易感性的选择性育种并没有导致自发性肿瘤性和非肿瘤性疾病的发生率随之增加。
