Castleman W L, Wong M M
Vet Pathol. 1982 Jul;19(4):355-64. doi: 10.1177/030098588201900402.
Lungs from dogs infected with adult, gravid Dirofilaria immitis but without microfilaria circulating in systemic vessels were studied by light and transmission electron microscopy. Microfilariae were seen within the pulmonary microvasculature and in interstitial areas of interalveolar septa. An acute inflammatory reaction characterized by aggregates of eosinophils, neutrophils, macrophages and lymphocytes was associated with intact microfilariae. Necrotic and fragmented microfilariae were surrounded by macrophages and epithelioid cells. Other lesions in interalveolar septa of dogs with chronic occult dirofilariasis included endothelial degeneration and hypertrophy, perivascular aggregates of plasma cells, hypertrophy and hyperplasia of smooth muscle cells, and interstitial fibrosis. The findings suggest that a cell-mediated hypersensitivity reaction is at least partially responsible for retention of microfilariae in pulmonary parenchyma of dogs with occult dirofilariasis.
对感染了成年妊娠型犬恶丝虫但全身血管中无微丝蚴循环的犬的肺组织进行了光镜和透射电镜研究。在肺微血管和肺泡间隔的间质区域可见微丝蚴。完整的微丝蚴伴有以嗜酸性粒细胞、中性粒细胞、巨噬细胞和淋巴细胞聚集为特征的急性炎症反应。坏死和破碎的微丝蚴被巨噬细胞和上皮样细胞包围。慢性隐匿性恶丝虫病犬肺泡间隔的其他病变包括内皮细胞变性和肥大、浆细胞血管周聚集、平滑肌细胞肥大和增生以及间质纤维化。这些发现表明，细胞介导的超敏反应至少部分导致了隐匿性恶丝虫病犬肺实质中微丝蚴的滞留。
