Pickles R W
Vet Rec. 1982 Apr 24;110(17):403-5. doi: 10.1136/vr.110.17.403.
The clinical efficacy of tiamulin given in the drinking water at levels of 0.0045 per cent for five days and 0.006 per cent for three days was evaluated for the treatment of swine dysentery in six clinical studies and compared with positive controls using tylosin at 0.02 per cent in the drinking water for five days and untreated controls. Efficacy was evaluated by assessment of the pigs' general appearance; the extent of diarrhoea and dehydration; performance, as measured by average daily gains and feed conversion efficiency; the presence or absence of Treponema hyodysenteriae in the faeces and mortality. As a result of statistical analysis of these parameters tiamulin medication was found to be an efficacious therapeutic regimen for naturally occurring swine dysentery when given at either level in the drinking water.
在六项临床研究中评估了泰妙菌素在饮水中以0.0045%的水平给药五天和以0.006%的水平给药三天治疗猪痢疾的临床疗效,并与在饮水中使用0.02%的泰乐菌素给药五天的阳性对照和未治疗对照进行比较。通过评估猪的总体外观、腹泻和脱水程度、以平均日增重和饲料转化率衡量的生产性能、粪便中是否存在猪痢疾短螺旋体以及死亡率来评估疗效。对这些参数进行统计分析的结果表明,当在饮水中以任何一种水平给药时,泰妙菌素给药都是治疗自然发生的猪痢疾的有效治疗方案。