Paches A I, Propp R M, Abdullin N A, Anokhin B M
Vopr Onkol. 1982;28(5):77-82.
The paper deals with a study of 42 cases of medullary carcinoma which accounts for 12.6% of all forms of thyroid cancer. The female-to-male ratio was 1.3:1, mean age - 45 years. Medullary carcinoma occurs sporadically in cases of familial endocrine syndrome. A case of Sipple's syndrome is reported. Medullar carcinoma is a hormonally-active tumor which produces calcitonin, the latter serving as a tumor marker for this carcinoma. Medullary carcinoma is characterized by bilateral involvement of the thyroid, which is more frequent in cases of familial disease, and a high rate of incidence of regional metastases (82.5%). Apart from clinical diagnostic means, the disease is chiefly identified cytologically and by calcitonin assays in blood plasma. It is mainly treated by surgery; 5- and 10-year survival rates are 87.2 and 80%, respectively.
本文对42例髓样癌进行了研究，髓样癌占所有甲状腺癌类型的12.6%。男女比例为1.3:1，平均年龄45岁。髓样癌散发性发生于家族性内分泌综合征病例中。报告了1例西普尔综合征病例。髓样癌是一种具有激素活性的肿瘤，可产生降钙素，后者作为该癌的肿瘤标志物。髓样癌的特点是甲状腺双侧受累，在家族性疾病中更为常见，区域转移发生率高（82.5%）。除临床诊断方法外，该疾病主要通过细胞学检查和血浆降钙素测定来确诊。主要通过手术治疗；5年和10年生存率分别为87.2%和80%。
