Tobe K
Acta Pathol Jpn. 1982 Mar;32(2):345-57.
An 80 micrometers bile duct with typical features of chronic non-suppurative destructive cholangitis was examined by electron microscopy. Many inflammatory cells, including lymphocytes, macrophages and plasma cells infiltrated among epithelial cells of the bile duct. Epithelial cells were compressed and deformed by infiltrating lymphocytes. These lymphocytes were in contact with epithelial cells at small points or large areas. The intercellular distance was about 10 or 20 nm at the contact areas. The mode of contact and intercellular distance coincided with the results of in vitro experiments on lymphocyte cytotoxicity against target cells. Some epithelial cells in contact with lymphocytes showed degenerative changes. Necrotic changes were observed in bile duct epithelial cells undergoing emperipolesis. The invading lymphocyte in the epithelial cell had osmiophilic substances on the surface. These sites of emperipolesis seem to be the areas of lymphocyte cytotoxicity against epithelial cells.
用电子显微镜检查了一条具有慢性非化脓性破坏性胆管炎典型特征的80微米胆管。许多炎症细胞，包括淋巴细胞、巨噬细胞和浆细胞浸润在胆管上皮细胞之间。浸润的淋巴细胞使上皮细胞受压并变形。这些淋巴细胞与上皮细胞在小点或大面积处接触。接触区域的细胞间距离约为10或20纳米。接触方式和细胞间距离与淋巴细胞对靶细胞细胞毒性的体外实验结果一致。一些与淋巴细胞接触的上皮细胞出现退行性改变。在发生侵入现象的胆管上皮细胞中观察到坏死改变。上皮细胞内侵入的淋巴细胞表面有嗜锇物质。这些侵入部位似乎是淋巴细胞对上皮细胞产生细胞毒性的区域。
