离子载体对淋巴细胞细胞代谢的影响。

Effect of ionophores on lymphocyte cellular metabolism.

作者信息

Arslan P, Miolo A, Montecucco C, Pozzan T

出版信息

Adv Exp Med Biol. 1982;141:481-9. doi: 10.1007/978-1-4684-8088-7_46.

Abstract

The effect of valinomycin, nigericin, gramicidin S and D, A23187 and X537A on respiration and cellular ATP content of rat spleen lymphocytes is presented. It has been found that while valinomycin and nigericin interfere with mitochondrial functions gramicidin D does not show an appreciable effect. These results are explained in terms of different ability of ionophores to re-distribute among intracellular membranes. A23187 and X537A, added with Ca2+, strongly enhanced O2 consumption and reduced cellular ATP content.

摘要

本文介绍了缬氨霉素、尼日利亚菌素、短杆菌肽S和D、A23187及X537A对大鼠脾脏淋巴细胞呼吸作用和细胞ATP含量的影响。已发现缬氨霉素和尼日利亚菌素会干扰线粒体功能，而短杆菌肽D未表现出明显作用。这些结果根据离子载体在细胞内膜间重新分布的不同能力进行了解释。添加Ca2+的A23187和X537A可强烈增强氧气消耗并降低细胞ATP含量。