Chung C S, Smith R G, Steinhoff P G, Mi M P
Am J Epidemiol. 1982 Jun;115(6):879-87. doi: 10.1093/oxfordjournals.aje.a113375.
In a prospective study the rate of ectopic pregnancies of women with prior induced abortion was contrasted to two sets of comparison groups: a large set of unmatched observations and a smaller subset of matched and refined data. The crude rates of ectopic pregnancy among 4004 abortion and 98,316 control pregnancies, excluding repeat pregnancies of the same women, were 0.57% and 0.49%, respectively. No significant association was detected between history of induced abortion and ectopic pregnancy based on the chi 2 analysis on unmatched data stratified by maternal age and marital status (relative risk = 1.18, 95% confidence limits (CL) 0.57-1.79) or the multivariate logistic regression analysis on the smaller set of data (relative risk = 1.34, 95% CL 0.66-2.72). Within pregnancies of the induced abortion group the risk of ectopic pregnancy was not related to abortion procedure, use of laminaria, number of prior induced abortions, or length of gestation at time of abortion. However, there was a clear association between the presence of post-abortion infection or retained secundines and ectopic pregnancy with a fivefold increase for those pregnancies of women with a history of these complications over those without these complications within the induced abortion cohort.
在一项前瞻性研究中，将有过人工流产史的女性的异位妊娠率与两组对照组进行了对比：一组是大量未匹配的观察对象，另一组是经过匹配和细化处理的较小数据子集。在4004例人工流产妊娠和98316例对照妊娠中（不包括同一女性的重复妊娠），异位妊娠的粗发病率分别为0.57%和0.49%。基于按母亲年龄和婚姻状况分层的未匹配数据进行的卡方分析（相对风险=1.18，95%置信区间（CL）0.57 - 1.79），或对较小数据集进行的多因素逻辑回归分析（相对风险=1.34，95% CL 0.66 - 2.72），均未检测到人工流产史与异位妊娠之间存在显著关联。在人工流产组的妊娠中，异位妊娠的风险与流产手术、是否使用海藻棒、既往人工流产次数或流产时的孕周无关。然而，流产后感染或胎盘胎膜残留与异位妊娠之间存在明显关联，在人工流产队列中，有这些并发症病史的女性的妊娠发生异位妊娠的风险比没有这些并发症的女性增加了五倍。
