Greenland S, Staisch K J, Brown N, Gross S J
Am J Obstet Gynecol. 1982 Jun 15;143(4):408-13. doi: 10.1016/0002-9378(82)90082-5.
We conducted a prospective study of the effects of marijuana use in 35 pregnancies. Thirty-six age-and parity-matched nonuser pregnancies were selected for comparison. (Users of other illicit drugs were excluded from study.) Users and nonusers were similar with respect to most potentially confounding prenatal risk factors, although users tended to come from lower income and educational backgrounds. Most adverse outcomes of pregnancy were too infrequent to allow reliable comparisons between the groups, but the infants born to users exhibited significantly more meconium staining (57% versus 25% in nonusers). Significant differences in duration of labor were also observed. The findings were not altered by statistical adjustments for various prenatal differences between the groups. Possible reasons for these findings are discussed. We also address the implications of these findings for further research.
我们对35例孕期使用大麻的影响进行了一项前瞻性研究。选取了36例年龄和胎次匹配的未使用者怀孕情况作为对照。（其他非法药物使用者被排除在研究之外。）尽管使用者往往来自低收入和低教育背景，但在大多数潜在的混杂产前风险因素方面，使用者和未使用者相似。大多数妊娠不良结局发生频率过低，无法在两组之间进行可靠比较，但使用者所生婴儿出现胎粪污染的比例显著更高（使用者为57%，未使用者为25%）。在产程持续时间上也观察到显著差异。对两组之间各种产前差异进行统计调整后，这些发现并未改变。讨论了这些发现的可能原因。我们还阐述了这些发现对进一步研究的意义。
