Perry M A, Bulkley G B, Kvietys P R, Granger D N
Am J Physiol. 1982 Jun;242(6):G565-9. doi: 10.1152/ajpgi.1982.242.6.G565.
The relation between oxygen uptake and blood flow in the isolated dog stomach was investigated under resting conditions and during intra-arterial infusion of isoproterenol or pentagastrin. Blood flows above and below control values were achieved by pump perfusion and partial arterial occlusion, respectively. In the resting stomach oxygen uptake increased from 0.4 to 1.5 ml.min-1.100 g-1 as blood flow increased from 4 to 40 ml.min-1.100 g-1 and then remained constant for blood flows up to 100 ml.min-1.100 g-1. Isoproterenol did not significantly alter the relation between oxygen uptake and blood flow. In pentagastrin-stimulated stomachs oxygen uptake was maintained at 2.5 ml.min-1.100 g-1 at blood flows between 40 and 100 ml.min-1.100 g-1 and decreased at blood flows below 40 ml.min-1.100 g-1. The results indicate that pentagastrin increases oxidative metabolism in the stomach. Despite this increase in oxygen consumption with pentagastrin, the general shape of the relation between blood flow and oxygen uptake remained the same and was simply displaced vertically above the control data.
在静息状态下以及动脉内输注异丙肾上腺素或五肽胃泌素期间，研究了离体犬胃中氧摄取与血流之间的关系。分别通过泵灌注和部分动脉闭塞实现高于和低于对照值的血流。在静息胃中，随着血流从4 ml·min⁻¹·100 g⁻¹增加到40 ml·min⁻¹·100 g⁻¹，氧摄取从0.4 ml·min⁻¹·100 g⁻¹增加到1.5 ml·min⁻¹·100 g⁻¹，然后在血流高达100 ml·min⁻¹·100 g⁻¹时保持恒定。异丙肾上腺素未显著改变氧摄取与血流之间的关系。在五肽胃泌素刺激的胃中，在血流为40至100 ml·min⁻¹·100 g⁻¹之间时，氧摄取维持在2.5 ml·min⁻¹·100 g⁻¹，而在血流低于40 ml·min⁻¹·100 g⁻¹时降低。结果表明，五肽胃泌素增加胃中的氧化代谢。尽管五肽胃泌素使氧消耗增加，但血流与氧摄取之间关系的总体形状保持不变，只是在对照数据上方垂直移位。
