Perry M A, Murphree D, Granger D N
Dig Dis Sci. 1982 Aug;27(8):675-9. doi: 10.1007/BF01393761.
Autoregulation of blood flow in the denervated, autoperfused dog stomach was studied before and during local intraarterial infusion of histamine. Histamine caused an increase in gastric blood flow and oxygen uptake. The increased oxygen uptake was due entirely to an increased blood flow, ie, oxygen extraction was not altered by histamine infusion. When oxygen uptake by the stomach was less than 2.0 ml/min/100 g, there was no evidence of blood flow autoregulation, while an oxygen uptake greater than 4.0 ml/min/100 g was consistently associated with blood flow autoregulation. The data indicate that histamine enhances the ability of the stomach to autoregulate its blood flow. This effect appears to be due to histamine's influence on gastric oxygen uptake.
在局部动脉内输注组胺之前和期间，对去神经支配、自身灌注的犬胃的血流自动调节进行了研究。组胺导致胃血流量和氧摄取增加。氧摄取增加完全是由于血流量增加，即组胺输注未改变氧提取率。当胃的氧摄取低于2.0毫升/分钟/100克时，没有血流自动调节的证据，而氧摄取大于4.0毫升/分钟/100克则始终与血流自动调节相关。数据表明，组胺增强了胃自动调节其血流的能力。这种作用似乎是由于组胺对胃氧摄取的影响。
