Donegan J O, Lobel J S, Gluckman J L
Am J Otolaryngol. 1982 Mar-Apr;3(2):141-4. doi: 10.1016/s0196-0709(82)80045-8.
Sickle cell disease is a common hereditary hematologic disorder characterized by the presence of a structurally abnormal hemoglobin molecule. Physicochemical properties of sickle hemoglobin result in a chronic hemolytic anemia and in vaso-occlusive episodes with ischemic injury of many tissues. In patients with sickle cell disease the otolaryngologist may be confronted with lesions affecting the ear, the bones and soft tissues, and the nervous system. Surgery and anesthesia also present special problems. An outline and discussion of these clinical concerns are presented.
镰状细胞病是一种常见的遗传性血液系统疾病，其特征是存在结构异常的血红蛋白分子。镰状血红蛋白的物理化学特性导致慢性溶血性贫血以及许多组织发生缺血性损伤的血管阻塞性发作。对于患有镰状细胞病的患者，耳鼻喉科医生可能会面临影响耳朵、骨骼和软组织以及神经系统的病变。手术和麻醉也存在特殊问题。本文将概述并讨论这些临床问题。
