Odetoyinbo O, Adekile A
Ann Otol Rhinol Laryngol. 1987 May-Jun;96(3 Pt 1):258-60. doi: 10.1177/000348948709600304.
Various degrees of hearing loss have been associated with sickle cell anemia. Fifty-six Nigerian children 6 to 15 years old were investigated for presence, type, and degree of hearing loss. Sensorineural hearing loss greater than or equal to 25 dB in two or more frequencies was found in 12 of 56 patients (21.4%). Tympanometry was normal in all patients, but acoustic reflex was elevated or absent in seven of 12 patients with hearing loss. Analysis of the data revealed a significant association between sensorineural hearing loss and the homozygous sickle cell disease, and a significant association between hearing loss and early occurrence of vaso-occlusive crisis. This latter finding suggest that the microvasculature of the cochlea in young infants may be more susceptible to occlusion during sickle cell crisis.
不同程度的听力损失与镰状细胞贫血有关。对56名6至15岁的尼日利亚儿童进行了听力损失的存在情况、类型和程度的调查。56名患者中有12名（21.4%）在两个或更多频率上出现了大于或等于25分贝的感音神经性听力损失。所有患者的鼓室图均正常，但12名听力损失患者中有7名的听觉反射增强或消失。数据分析显示，感音神经性听力损失与纯合子镰状细胞病之间存在显著关联，听力损失与血管闭塞性危象的早期发生之间也存在显著关联。后一项发现表明，幼儿期镰状细胞危象期间，耳蜗的微脉管系统可能更容易发生闭塞。
