Wethers D L
Am J Pediatr Hematol Oncol. 1982 Spring;4(1):47-53.
The period of adolescence in the patient with sickle cell disease seems to be a period of relative calm, medically speaking. The current 5-year prospective Cooperative Study of the Clinical Course of Sickle Cell Disease should demonstrate the actual spectrum of disease in this age group. The recent literature documents with significant relationship between retardation of growth and sexual maturation in the child with sickle cell disease, an effect which seems independent of the severity of the disease. Several other major problems in the adolescent are discussed, including psychological disturbances, leg ulcers, aseptic necrosis, pulmonary disease, priapism, stroke, cholelithiasis, and birth control. A retrospective series of 76 cases of sickle cell disease is briefly presented and the complication occurring during the second decade of life are reviewed.
从医学角度来看，镰状细胞病患者的青春期似乎是一个相对平静的时期。目前正在进行的为期5年的镰状细胞病临床病程前瞻性合作研究，应能展示该年龄组疾病的实际范围。最近的文献记载，镰状细胞病患儿的生长发育迟缓和性成熟之间存在显著关联，这种影响似乎与疾病的严重程度无关。文中还讨论了青少年期的其他几个主要问题，包括心理障碍、腿部溃疡、无菌性坏死、肺部疾病、阴茎异常勃起、中风、胆石症和节育。本文简要介绍了76例镰状细胞病的回顾性系列病例，并对第二个十年中出现的并发症进行了综述。
