Schlag G, Redl H
Anasth Intensivther Notfallmed. 1982 Apr;17(2):86-91.
Using intravital lung biopsies and a shock model, which is based on preceding ultrastructural studies in humans, we could detect leucostasis and swelling of endothelial cells as a sign of the "lung in shock". These events are responsible for the resulting irreversible lung deterioration, though they are not accessible to clinical diagnosis. Therefore one must perform prophylactic treatment such as artificial ventilation, pharmacological influence on granulocyte functions including the release of lysosomal enzymes und oxygen radicals. In this way ARDS must be avoided, because there is still a mortality of about 60% with this syndrome.
利用基于人类超微结构前期研究的活体肺活检和休克模型，我们能够检测到白细胞停滞和内皮细胞肿胀，这是“休克肺”的迹象。这些事件是导致不可逆肺损伤的原因，尽管临床诊断无法检测到它们。因此，必须进行预防性治疗，如人工通气、对粒细胞功能的药理学影响，包括溶酶体酶和氧自由基的释放。通过这种方式必须避免急性呼吸窘迫综合征（ARDS），因为该综合征的死亡率仍约为60%。
