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[成人急性呼吸窘迫综合征时肺的超微结构改变]

[Ultrastructural changes in the lung in acute adult respiratory distress syndrome].

作者信息

Szemenyei K, Széll K, Kádas L

出版信息

Morphol Igazsagugyi Orv Sz. 1980 Apr;20(2):98-106.

PMID:7266509
Abstract

Morphological alterations of the lung in respiratory distress syndrome of adults (ARDS) were analyzed in 10 cases with traumatic-and septic shock, laryngitis subglottica descendens and bronchopneumonia. For the better understanding of the pathomechanism of the disease in addition to the standard methods, first of all ultrastructural alterations were studied. Two phases of the morphologic alterations could be distinguished, the phase of the destruction and the phase of the repair. These two processes are not sharply distinguishable. Genesis of the characteristic histological alterations (damage to the epithelial and endothelial cells, formation of hyaline membranes, microcoagulation, proliferation of the type II pneumocytes and fibroblasts, fibrosis) is discussed, with regard to the data of the literature.

摘要

对10例创伤性和感染性休克、下呼吸道喉炎及支气管肺炎患者的成人呼吸窘迫综合征(ARDS)肺部形态学改变进行了分析。为了更好地理解该疾病的发病机制,除了标准方法外,首先研究了超微结构改变。形态学改变可分为两个阶段,即破坏阶段和修复阶段。这两个过程并无明显界限。结合文献资料,对特征性组织学改变(上皮细胞和内皮细胞损伤、透明膜形成、微凝血、Ⅱ型肺泡上皮细胞和成纤维细胞增殖、纤维化)的发生机制进行了讨论。

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