Bentley J B, Vaughan R W, Gandolfi A J, Cork R C
Anesthesiology. 1982 Aug;57(2):94-7. doi: 10.1097/00000542-198208000-00005.
Serum levels of inorganic fluoride, trifluoroacetic acid, and bromide ion were measured at various time intervals following two hours of halothane anesthesia in 17 morbidly obese and eight nonobese patients. Ionic fluoride, a marker of reductive halothane metabolism, increased in the obese but not the nonobese patients. This is of concern since reductive halothane metabolism is associated with hepatoxicity in animals. In addition, serum bromide levels were higher after 48 h in the obese patients compared to the nonobese patients (mean +/- SE, 1,311 +/- 114 vs. 787 +/- 115 microM, P less than 0.01). Sedative levels of bromide were not attained in any patient. Peak trifluoroacetic acid levels were similar in the two patient groups. Sex age, medication intake, and smoking history had no influence on the halothane metabolite levels found in this study.
在17例病态肥胖患者和8例非肥胖患者中，于氟烷麻醉两小时后的不同时间间隔测量血清无机氟、三氟乙酸和溴离子水平。离子氟是氟烷还原代谢的标志物，在肥胖患者中升高，而在非肥胖患者中未升高。这令人担忧，因为氟烷还原代谢与动物肝毒性有关。此外，肥胖患者在48小时后的血清溴水平高于非肥胖患者（均值±标准误，1311±114对787±115微摩尔，P<0.01）。所有患者均未达到溴的镇静水平。两个患者组的三氟乙酸峰值水平相似。性别、年龄、药物摄入和吸烟史对本研究中发现的氟烷代谢物水平没有影响。
