Meldgaard O T, Cold G E
Acta Anaesthesiol Scand. 1979 Dec;23(6):513-18. doi: 10.1111/j.1399-6576.1979.tb01481.x.
Serum bromide was determined in 30 patients during the first few postoperative days after general anaesthesia with halothane. The material comprised a group of younger patients (19-50 years) and a group of elderly patients (greater than 70 years), neither of whom received thiomebumal induction, and a group of younger patients (19-50 years) who received thiomebumal induction. The changes in serum bromide were independent of age and induction with barbiturate, and a maximum rise in serum bromide was found most often 2-3 days after the anaesthesia. All groups showed a rise in serum bromide to therapeutically sedative concentrations, and a significant correlation was found between MAC-hours halothane exposure and serum bromide.
在30例接受氟烷全身麻醉后的术后头几天测定了血清溴化物含量。研究对象包括一组年轻患者（19 - 50岁）和一组老年患者（70岁以上），两组均未接受硫喷妥钠诱导麻醉，以及一组接受硫喷妥钠诱导麻醉的年轻患者（19 - 50岁）。血清溴化物的变化与年龄和巴比妥酸盐诱导无关，且血清溴化物的最大升高最常出现在麻醉后2 - 3天。所有组的血清溴化物均升高至具有治疗性镇静作用的浓度，并且发现氟烷暴露的最低肺泡有效浓度小时数与血清溴化物之间存在显著相关性。
